Biomolecules & Therapeutics 2025; 33(1): 1~233
Preface
Emerging and Promising Keywords in Biomolecules and Therapeutics for 21st Century Diseases
Hyun-Jeong Ko and Chang Hoon Lee
Biomolecules & Therapeutics 2025; 33(1): 1-4  
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Reviews
An Overview of Existing and Emerging Weight-Loss Drugs to Target Obesity-Related Complications: Insights from Clinical Trials
Mi Kyung Kim and Hye Soon Kim
Biomolecules & Therapeutics 2025; 33(1): 5-17  
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New Insights into AMPK, as a Potential Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease and Hepatic Fibrosis
Haeun An, Yerin Jang, Jungin Choi, Juhee Hur, Seojeong Kim and Youngjoo Kwon
Biomolecules & Therapeutics 2025; 33(1): 18-38  
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Natural Compounds in Kidney Disease: Therapeutic Potential and Drug Development
Vijayakumar Natesan and Sung-Jin Kim
Biomolecules & Therapeutics 2025; 33(1): 39-53  
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Probiotics as Potential Treatments for Neurodegenerative Diseases: a Review of the Evidence from in vivo to Clinical Trial
Jin Hee Kim, Yujin Choi, Seungmin Lee and Myung Sook Oh
Biomolecules & Therapeutics 2025; 33(1): 54-74  
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The Dual Role of Survival Genes in Neurons and Cancer Cells: a Strategic Clinical Application of DX2 in Neurodegenerative Diseases and Cancer
Kyunghwa Baek
Biomolecules & Therapeutics 2025; 33(1): 75-85  
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Intra-Articular Injection of Stem Cells for the Regeneration of Knee Joint Cartilage: a Therapeutic Option for Knee Osteoarthritis — a Narrative Review
Hyun Jae Lee, Rajib Hossain, Chang-Heon Baek, Choong Jae Lee and Sun-Chul Hwang
Biomolecules & Therapeutics 2025; 33(1): 86-94  
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The Emerging Threat of Micro- and Nanoplastics on the Maturation and Activity of Immune Cells
Kang-Bin Dan, Ji Yoon Yoo and Hyeyoung Min
Biomolecules & Therapeutics 2025; 33(1): 95-105  
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Original Articles
The Anti-Inflammatory Activities of Benzylideneacetophenone Derivatives in LPS Stimulated BV2 Microglia Cells and Mice
Mijin Kim, Seungmin Kang and Seikwan Oh
Biomolecules & Therapeutics 2025; 33(1): 106-116  
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Glutathione’s Role in Liver Metabolism and Hangover Symptom Relief: Dysregulation of Protein S-Glutathionylation and Antioxidant Enzymes
Hwa-Young Lee, Geum-Hwa Lee, Do-Sung Kim, Young Jae Lim, Boram Cho, Hojung Jung, Hyun-shik Choi, Soonok Sa, Wookyung Chung, Hyewon Lee, Myoung Ja Chung, Junghyun Kim and Han-Jung Chae
Biomolecules & Therapeutics 2025; 33(1): 117-128  
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6-Gingerol Induced Apoptosis and Cell Cycle Arrest in Glioma Cells via MnSOD and ERK Phosphorylation Modulation
Sher-Wei Lim, Wei-Chung Chen, Huey-Jiun Ko, Yu-Feng Su, Chieh-Hsin Wu, Fu-Long Huang, Chien-Feng Li and Cheng Yu Tsai
Biomolecules & Therapeutics 2025; 33(1): 129-142  
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Taurine Synthesis by 2-Aminoethanethiol Dioxygenase as a Vulnerable Metabolic Alteration in Pancreatic Cancer
Hoonsik Nam, Woohyung Lee, Yun Ji Lee, Jin-Mo Kim, Kyung Hee Jung, Soon-Sun Hong, Song Cheol Kim and Sunghyouk Park
Biomolecules & Therapeutics 2025; 33(1): 143-154  
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Design, Screening and Development of Asymmetric siRNAs Targeting the MYC Oncogene in Triple-Negative Breast Cancer
Negesse Mekonnen, Myeung-Ryun Seo, Hobin Yang, Chaithanya Chelakkot, Jun Young Choi, Sungyoul Hong, Kyoung Song and Young Kee Shin
Biomolecules & Therapeutics 2025; 33(1): 155-169  
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Low-Dose Perifosine, a Phase II Phospholipid Akt Inhibitor, Selectively Sensitizes Drug-Resistant ABCB1-Overexpressing Cancer Cells
Jae Hyeon Park, Haeun Lee, Tian Zheng, Joo Kyung Shin, Sungpil Yoon and Hyung Sik Kim
Biomolecules & Therapeutics 2025; 33(1): 170-181  
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Epigenetic Regulation of Nuclear Factor Erythroid-2-Related Factor 2 in Colorectal Cancer Cells Resistant to Ionizing Radiation
Kyoung Ah Kang, Jinny Park, Mei Jing Piao, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Herath Mudiyanselage Maheshika Madhuwanthi Senavirathna, Jung-Hwan Kim, Suk Ju Cho and Jin Won Hyun
Biomolecules & Therapeutics 2025; 33(1): 182-192  
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Translationally Controlled Tumor Protein Enhances Angiogenesis in Ovarian Tumors by Activating Vascular Endothelial Growth Factor Receptor 2 Signaling
Seung Bae Rho, Boh-Ram Kim, Seung-Hoon Lee and Chang Hoon Lee
Biomolecules & Therapeutics 2025; 33(1): 193-202  
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Combination of Cannabidiol with Taurine Synergistically Treated Periodontitis in Rats
Se Woong Kim, Saroj Kumar Shrestha, Badmaarag-Altai Chuluunbaatar and Yunjo Soh
Biomolecules & Therapeutics 2025; 33(1): 203-209  
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Tanshinone, a Natural NADPH Oxidase Inhibitor, Mitigates Testosterone-Induced Hair Loss
Yeo Kyu Hur, Jin Yeong Chae, Min Hye Choi, Kkotnara Park, Da-Woon Bae, Soo-Bong Park, Sun-Shin Cha, Hye Eun Lee, In Hye Lee and Yun Soo Bae
Biomolecules & Therapeutics 2025; 33(1): 210-220  
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C-Peptide Ameliorates Particulate Matter 2.5-Induced Skin Cell Apoptosis by Inhibiting NADPH Oxidation
Pincha Devage Sameera Madushan Fernando, Mei Jing Piao, Herath Mudiyanselage Udari Lakmini Herath, Kyoung Ah Kang, Kwon-Soo Ha, Sungwook Chae and Jin Won Hyun
Biomolecules & Therapeutics 2025; 33(1): 221-230  
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Errata
Erratum to "Abiraterone Acetate Attenuates SARS-CoV-2 Replication by Interfering with the Structural Nucleocapsid Protein" [Biomol Ther 30(5), 427-434 (2022)]
Jinsoo Kim, Seok Young Hwang, Dongbum Kim, Minyoung Kim, Kyeongbin Baek, Mijeong Kang, Seungchan An, Junpyo Gong, Sangkyu Park, Mahmoud Kandeel, Younghee Lee, Minsoo Noh and Hyung-Joo Kwon
Biomolecules & Therapeutics 2025; 33(1): 231-232  
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Erratum to "Investigating the Immune-Stimulating Potential of β-Glucan from Aureobasidium pullulans in Cancer Immunotherapy" [Biomol Ther 32(5), 556-567 (2024)]
Jae-Hyeon Jeong, Dae-Joon Kim, Seong-Jin Hong, Jae-Hee Ahn, Dong-Ju Lee, Ah-Ra Jang, Sungyun Kim, Hyun-Jong Cho, Jae-Young Lee, Jong-Hwan Park, Young-Min Kim and Hyun-Jeong Ko
Biomolecules & Therapeutics 2025; 33(1): 233-233  
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e-submission

Drug Discovery Perspectives of Antisense Oligonucleotides
Yeonjoon Kim*
Received: January 3, 2023; Revised: February 12, 2023; Accepted: February 13, 2023
Phytochemicals That Act on Synaptic Plasticity as Potential Prophylaxis against Stress-Induced Depressive Disorder
Soojung Yoon, Hamid Iqbal, Sun Mi Kim and Mirim Jin
Received: September 1, 2022; Revised: December 6, 2022; Accepted: December 20, 2022
Structural Insights for β-Lactam Antibiotics
Dogyeoung Kim, Sumin Kim, Yongdae Kwon, Yeseul Kim, Hyunjae Park, Kiwoong Kwak, Hyeonmin Lee, Jung Hun Lee, Kyung-Min Jang, Donghak Kim, Sang Hee Lee and Lin-Woo Kang
Received: January 11, 2023; Revised: January 19, 2023; Accepted: January 20, 2023

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