Biomolecules & Therapeutics 2025; 33(2): 235~415
Reviews
Pro-Oxidative and Inflammatory Actions of Extracellular Hemoglobin and Heme: Molecular Events and Implications for Alzheimer’s and Parkinson Disease
Nicole Bon Campomayor, Hee Jin Kim and Mikyung Kim
Biomolecules & Therapeutics 2025; 33(2): 235-248  
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Allergy Inhibition Using Naturally Occurring Compounds Targeting Thymic Stromal Lymphopoietin Pathways: a Comprehensive Review
Le Ba Vinh, Kyeong Seon Lee, Yoo Kyong Han, Young Jun Kim, Suzy Kim, Abdul Bari Shah, Youngjoo Byun and Ki Yong Lee
Biomolecules & Therapeutics 2025; 33(2): 249-267  
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Original Articles
A Novel Histone Deacetylase 6 Inhibitor, 4-FHA, Improves Scopolamine-Induced Cognitive and Memory Impairment in Mice
Jee-Yeon Seo, Jisoo Kim, Yong-Hyun Ko, Bo-Ram Lee, Kwang-Hyun Hur, Young Hoon Jung, Hyun-Ju Park, Seok-Yong Lee and Choon-Gon Jang
Biomolecules & Therapeutics 2025; 33(2): 268-277  
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Structure-Activity Relationship of NMDA Receptor Ligands and Their Activities on the ERK Activation through Metabotropic Signaling Pathway
Dooti Kundu, Mengling Wang, Suresh Paudel, Shujie Wang, Choon-Gon Jang and Kyeong-Man Kim
Biomolecules & Therapeutics 2025; 33(2): 278-285  
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Neuroprotective Effect of β-Lapachone against Glutamate-Induced Injury in HT22 Cells
Hae Rim Lee, Hye Jin Jee and Yi-Sook Jung
Biomolecules & Therapeutics 2025; 33(2): 286-296  
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Isorhamnetin Alleviates Inflammation-Induced Crosstalk between Kynurenine Pathway and Gut Microbiota in Depressed Mice
Mengjie Xu, Wei He, Ke Yan, Xinru Gao, Jun Li, Dongyue Xu, Jiao Xiao and Tingxu Yan
Biomolecules & Therapeutics 2025; 33(2): 297-310  
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Primed Mesenchymal Stem Cells by IFN-γ and IL-1β Ameliorate Acute Respiratory Distress Syndrome through Enhancing Homing Effect and Immunomodulation
Taeho Kong, Su Kyoung Seo, Yong-Seok Han, Woo Min Seo, Bokyong Kim, Jieun Kim, Young-Jae Cho, Seunghee Lee and Kyung-Sun Kang
Biomolecules & Therapeutics 2025; 33(2): 311-324  
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Galangin Regulates Mucin 5AC Gene Expression via the Nuclear Factor-κB Inhibitor α/Nuclear Factor-κB p65 Pathway in Human Airway Epithelial Cells
Rajib Hossain, Hyun Jae Lee and Choong Jae Lee
Biomolecules & Therapeutics 2025; 33(2): 325-330  
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Daurisoline Inhibits Progression of Triple-Negative Breast Cancer by Regulating the γ-Secretase/Notch Axis
Xiangyi Zhan, Xiaoyong Chen, Mei Feng, Kuo Yao, Kefan Yang and Hui Jia
Biomolecules & Therapeutics 2025; 33(2): 331-343  
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Licochalcone D Exerts Antitumor Activity in Human Colorectal Cancer Cells by Inducing ROS Generation and Phosphorylating JNK and p38 MAPK
Seung-On Lee, Sang Hoon Joo, Seung-Sik Cho, Goo Yoon, Yung Hyun Choi, Jin Woo Park, Kwon-Yeon Weon and Jung-Hyun Shim
Biomolecules & Therapeutics 2025; 33(2): 344-354  
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Resveratrol from Peanut Sprout Extract Promotes NK Cell Activation and Antitumor Activity
Hyunmin Chung, Seong Ho Bak, Eunju Shin, Taeho Park, Jinwoo Kim, Hanseul Jeong, Haiyoung Jung, Suk Ran Yoon and Ji-Yoon Noh
Biomolecules & Therapeutics 2025; 33(2): 355-364  
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Artesunate Inhibits the Proliferation and Migration of Cutaneous Squamous Cell Carcinoma by Regulating the SLC7A11-GPX4 Pathway via the p300-p53 Axis
Xinyan Huang, Wenxi Wang, Songzhao Zhang, Lili Li and Jihui Huang
Biomolecules & Therapeutics 2025; 33(2): 365-377  
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Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells
Mi Jeong Kwon, Pawan Kumar Raut, Jeong-Hoon Jang and Kyung-Soo Chun
Biomolecules & Therapeutics 2025; 33(2): 378-387  
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Quercetin-3-Methyl Ether Induces Early Apoptosis to Overcome HRV1B Immune Evasion, Suppress Viral Replication, and Mitigate Inflammatory Pathogenesis
Jae-Hyoung Song, Seo-Hyeon Mun, Sunil Mishra, Seong-Ryeol Kim, Heejung Yang, Sun Shim Choi, Min-Jung Kim, Dong-Yeop Kim, Sungchan Cho, Youngwook Ham, Hwa-Jung Choi, Won-Jin Baek, Yong Soo Kwon, Jae-Hoon Chang and Hyun-Jeong Ko
Biomolecules & Therapeutics 2025; 33(2): 388-398  
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An Amphibians-Derived Protein Provides Novel Biotherapeutics for Various Wounds Treatment
Hao-Ran Chen, Nan Zhou, Yu-Da Liu and Li-Hua Peng
Biomolecules & Therapeutics 2025; 33(2): 399-407  
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Piperine Regulates Melanogenesis through ERK Activation and Proteasomal Degradation of MITF
Jun Hyeong Lee, Jieun Lee, Sukanya Dej-adisai and Jae Sung Hwang
Biomolecules & Therapeutics 2025; 33(2): 408-414  
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Erratum
Erratum to "Potential Role of Dietary Salmon Nasal Cartilage Proteoglycan on UVB-Induced Photoaged Skin" [Biomol Ther 32(2), 249-260 (2024)]
Hae Ran Lee, Seong-Min Hong, Kyohee Cho, Seon Hyeok Kim, Eunji Ko, Eunyoo Lee, Hyun Jin Kim, Se Yeong Jeon, Seon Gil Do and Sun Yeou Kim
Biomolecules & Therapeutics 2025; 33(2): 415-415  
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e-submission

Drug Discovery Perspectives of Antisense Oligonucleotides
Yeonjoon Kim*
Received: January 3, 2023; Revised: February 12, 2023; Accepted: February 13, 2023
Synergistic Renoprotective Effect of Melatonin and Zileuton by Inhibition of Ferroptosis via the AKT/mTOR/NRF2 Signaling in Kidney Injury and Fibrosis
Kyung Hee Jung, Sang Eun Kim, Han Gyeol Go, Yun Ji Lee, Min Seok Park, Soyeon Ko, Beom Seok Han, Young-Chan Yoon, Ye Jin Cho, Pureunchowon Lee, Sang-Ho Lee, Kipyo Kim and Soon-Sun Hong
Received: March 23, 2023; Revised: April 7, 2023; Accepted: April 17, 2023
Inhibition of DNMT3B and PI3K/AKT/mTOR and ERK Pathways as a Novel Mechanism of Volasertib on Hypomethylating Agent-Resistant Cells
Eun-Ji Choi, Bon-Kwan Koo, Eun-Hye Hur, Ju Hyun Moon, Ji Yun Kim, Han-Seung Park, Yunsuk Choi, Kyoo-Hyung Lee, Jung-Hee Lee, Eun Kyung Choi and Je-Hwan Lee
Received: September 2, 2022; Revised: October 25, 2022; Accepted: October 26, 2022

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