Biomolecules & Therapeutics 2021; 29(3): 249~351
Multifactorial Traits of SARS-CoV-2 Cell Entry Related to Diverse Host Proteases and Proteins
Jaehwan You, Jong Hyeon Seok, Myungsoo Joo, Joon-Yong Bae, Jin Il Kim, Man-Seong Park,* and Kisoon Kim,*
Biomolecules & Therapeutics 2021; 29(3): 249-262  
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Recent Advances of Therapeutic Targets for the Treatment of Periodontal Disease
Woo Jin Kim, Yunjo Soh,* and Seok-Mo Heo,*
Biomolecules & Therapeutics 2021; 29(3): 263-267  
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Original Articles
Antiviral Efficacy of Pralatrexate against SARS-CoV-2
Joon-Yong Bae, Gee Eun Lee, Heedo Park, Juyoung Cho, Jeonghun Kim, Jungmin Lee, Kisoon Kim, Jin Il Kim,* and Man-Seong Park,*
Biomolecules & Therapeutics 2021; 29(3): 268-272  
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Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection
Byoung Kwon Park, Dongbum Kim, Sangkyu Park, Sony Maharjan, Jinsoo Kim, Jun-Kyu Choi, Madhav Akauliya, Younghee Lee,* and Hyung-Joo Kwon,*
Biomolecules & Therapeutics 2021; 29(3): 273-281  
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Discovery of New Fusion Inhibitor Peptides against SARS-CoV-2 by Targeting the Spike S2 Subunit
Mahmoud Kandeel,*, Mizuki Yamamoto, Hideki Tani, Ayako Kobayashi, Jin Gohda, Yasushi Kawaguchi, Byoung Kwon Park, Hyung-Joo Kwon,*, Jun-ichiro Inoue,* and Abdallah Alkattan
Biomolecules & Therapeutics 2021; 29(3): 282-289  
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3’-O-Acetyl-24-Epi-7,8-Didehydrocimigenol-3-O-β-DXylopryranoside Decreases Amyloid Beta Production in Amyloid Precursor Protein-Transfected HeLa Cells
Sang-Bin Lee, Ansun Park, Chi Thanh Ma, Young Ho Kim and Hyun Ok Yang,*
Biomolecules & Therapeutics 2021; 29(3): 290-294  
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Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS
Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Do-Yeon Kim and Hee-Sun Kim*
Biomolecules & Therapeutics 2021; 29(3): 295-302  
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Kaempferol Regulates the Expression of Airway MUC5AC Mucin Gene via IκBα-NF-κB p65 and p38-p44/42-Sp1 Signaling Pathways
Xin Li, Fengri Jin, Hyun Jae Lee,* and Choong Jae Lee,*
Biomolecules & Therapeutics 2021; 29(3): 303-310  
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Suppression of Foxo3-Gatm by miR-132-3p Accelerates Cyst Formation by Up-Regulating ROS in Autosomal Dominant Polycystic Kidney Disease
Seonju Choi, Do Yeon Kim, Yejin Ahn, Eun Ji Lee and Jong Hoon Park*
Biomolecules & Therapeutics 2021; 29(3): 311-320  
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Protective Role of Transduced Tat-Thioredoxin1 (Trx1) against Oxidative Stress-Induced Neuronal Cell Death via ASK1-MAPK Signal Pathway
Eun Ji Yeo, Won Sik Eum, Hyeon Ji Yeo, Yeon Joo Choi, Eun Jeong Sohn, Hyun Jung Kwon, Dae Won Kim, Duk-Soo Kim, Sung-Woo Cho, Jinseu Park, Kyu Hyung Han, Keun Wook Lee, Jong Kook Park, Min Jea Shin,* and Soo Young Choi,*
Biomolecules & Therapeutics 2021; 29(3): 321-330  
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SP-8356, a (1S)-(-)-Verbenone Derivative, Inhibits the Growth and Motility of Liver Cancer Cells by Regulating NF-κB and ERK Signaling
Dong Hwi Kim, Hyo Jeong Yong, Sunam Mander, Huong Thi Nguyen, Lan Phuong Nguyen, Hee-Kyung Park, Hyo Kyeong Cha, Won-Ki Kim,* and Jong-Ik Hwang,*
Biomolecules & Therapeutics 2021; 29(3): 331-341  
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Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction
Alba Herrero, Aitor Benedicto*, Irene Romayor, Elvira Olaso and Beatriz Arteta
Biomolecules & Therapeutics 2021; 29(3): 342-351  
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Poncirin Inhibits Osteoclast Differentiation and Bone Loss through Down-Regulation of NFATc1 In Vitro and In Vivo
Kwang-Hoon Chun, Hyun Chul Jin, Ki Sung Kang, Tong-Shin Chang and Gwi Seo Hwang
Received: November 5, 2018; Revised: January 24, 2019; Accepted: April 3, 2019
Alternative Methods for Testing Botulinum Toxin: Current Status and Future Perspectives
Mahesh Raj Nepal and Tae Cheon Jeong
Received: November 29, 2019; Revised: February 6, 2020; Accepted: February 17, 2020
Small Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Fusion by Targeting Cavities on Heptad Repeat Trimers
Mahmoud Kandeel, Mizuki Yamamoto, Abdulla Al-Taher, Aya Watanabe, Kentaro Oh-hashi, Byoung Kwon Park, Hyung-Joo Kwon, Jun-ichiro Inoue and Mohammed Al-Nazawi
Received: December 2, 2019; Revised: January 13, 2020; Accepted: January 23, 2020

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