Biomolecules & Therapeutics
Anti-Melanogenic Activity of Undecylprodigiosin, a Red Pigment Isolated from a Marine Streptomyces sp. SNA-077
Chaeyoung Lee1,†, Jung Min Park2,†, Prima F. Hillman1,†, Minyi Yoo1, Hye Yeon Kim2, Chang-Seok Lee2,* and Sang-Jip Nam1,*
1Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760,
2Department of Beauty and Cosmetic Science, Eulji University, Seongnam 13135, Republic of Korea
*E-mail: (Lee CS), (Nam SJ)
Tel: +82-31-740-7549 (Lee CS), +82-2-3277-6805 (Nam SJ)
Fax: +82-31-740-7358 (Lee CS), +82-2-3277-4546 (Nam SJ)
The first three authors contributed equally to this work.
Received: November 28, 2023; Revised: January 15, 2024; Accepted: February 14, 2024; Published online: April 23, 2024.
© The Korean Society of Applied Pharmacology. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Bioassay and HPLC-UV guided fractionations of the crude extract of marine-derived Streptomyces sp. SNA-077 have led to the isolation of a red pigment, undecylprodigiosin (1). The chemical structure of undecylprodigiosin (1) was revealed by the interpretation of NMR and mass spectroscopic (MS) data. Further, anti-melanogenic effects of undecylprodigiosin (1) were investigated. First, the melanin contents of undecylprodigiosin (1)-treated B16 cells were evaluated. Furthermore, undecylprodigiosin (1) significantly inhibited the key enzymes involved in melanogenesis, including tyrosinase, tyrosinase related protein-1 (TYRP-1), and dopachrome tautomerase (DCT). The mRNA and protein expression levels of Microphthalmia-associated transcriptian factor (MiTF), a critical transcription factor for tyrosinase gene expression, were also suppressed by undecylprodigiosin (1) treatment in B16 analyses. Collectively, our results suggest for the first time that undecylprodigiosin (1), a potent component isolated from an extract of marine Streptomyces sp. SNA-077, critically exerts the anti-melanogenic ability for melanin synthesis.
Keywords: Undecylprodigiosin, Streptomyces sp., Red pigments, Marine natural products, Anti-melanogenic

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