Biomolecules & Therapeutics  https://doi.org/10.4062/biomolther.2023.118
Inhaled Volatile Molecules-Responsive TRP Channels as Non-Olfactory Receptors
Hyungsup Kim1, Minwoo Kim2 and Yongwoo Jang2,3,*
1Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792,
2Department of Medical and Digital Engineering, College of Engineering, Hanyang University, Seoul 04736,
3Department of Pharmacology, College of Medicine, Hanyang University, Seoul 04736, Republic of Korea
*E-mail: ywjang@hanyang.ac.kr
Tel: +82-2-2220-0665, Fax: +82-2-958-7034
Received: June 20, 2023; Revised: July 8, 2023; Accepted: July 12, 2023; Published online: August 8, 2023.
© The Korean Society of Applied Pharmacology. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Generally, odorant molecules are detected by olfactory receptors, which are specialized chemoreceptors expressed in olfactory neurons. Besides odorant molecules, certain volatile molecules can be inhaled through the respiratory tract, often leading to pathophysiological changes in the body. These inhaled molecules mediate cellular signaling through the activation of the Ca2+-permeable transient receptor potential (TRP) channels in peripheral tissues. This review provides a comprehensive overview of TRP channels that are involved in the detection and response to volatile molecules, including hazardous substances, anesthetics, plant-derived compounds, and pheromones. The review aims to shed light on the biological mechanisms underlying the sensing of inhaled volatile molecules. Therefore, this review will contribute to a better understanding of the roles of TRP channels in the response to inhaled molecules, providing insights into their implications for human health and disease.
Keywords: Transient receptor potential channel, TRPV1, TRPA1, Volatile organic compound, Non-olfactory receptors

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