Synergistic Renoprotective Effect of Melatonin and Zileuton by Inhibition of Ferroptosis via the AKT/mTOR/NRF2 Signaling in Kidney Injury and Fibrosis
Kyung Hee Jung1,†, Sang Eun Kim1,†, Han Gyeol Go1, Yun Ji Lee1, Min Seok Park1, Soyeon Ko1, Beom Seok Han1, Young-Chan Yoon1, Ye Jin Cho1, Pureunchowon Lee1, Sang-Ho Lee2, Kipyo Kim3,* and Soon-Sun Hong1,*
1Department of Medicine, College of Medicine, and Program in Biomedical Science & Engineering, Inha University, Incheon 22332, 2Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul 02453, 3Divison of Nephrology and Hypertension, Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, Incheon 22332, Republic of Korea
*E-mail:
hongs@inha.ac.kr (Hong SS),
kpkidney@inha.ac.kr (Kim K)
Tel: +82-32-890-3683 (Hong SS), +82-32-890-3246 (Kim K)
Fax: +82-32-890-2462 (Hong SS), +82-32-890-2462 (Kim K)
†The first two authors contributed equally to this work.