Biomolecules & Therapeutics
Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance
Kyung-Soo Chun1 and Sang Hoon Joo2,*
1College of Pharmacy, Keimyung University, Daegu 42601,
2Department of Pharmacy, Daegu Catholic University, Gyeongsan 38430, Republic of Korea
Tel: +82-53-850-3614, Fax: +82-53-359-6729
Received: January 28, 2022; Revised: March 29, 2022; Accepted: March 30, 2022; Published online: April 20, 2022.
© The Korean Society of Applied Pharmacology. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
5-Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5-FU, and new strategies are required to overcome the resistance. Reactive oxygen species (ROS) and antioxidants are balanced differently in both normal and cancer cells. Modulating ROS can be one method of overcoming 5-FU resistance. This review summarizes selected compounds and endogenous cellular targets modulating ROS generation to overcome 5-FU resistance.
Keywords: Reactive oxygen species, Cancer, Resistance, 5-Fluorouracil

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