Biomolecules & Therapeutics  https://doi.org/10.4062/biomolther.2021.192
The Role of Mitochondrial Biogenesis Dysfunction in Diabetic Cardiomyopathy
Li-Chan Tao1, Ting-ting Wang1, Lu Zheng1, Fei Hua1,* and Jian-Jun Li2,*
1The Third Affiliated Hospital of Soochow University, Juqian Road, Changzhou 213000,
2State Key Laboratory of Cardiovascular Diseases, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
*E-mail: Huafei1970@suda.cn (Hua F), lijianjun938@126.com (Li JJ)
Tel: +86-13806119768 (Hua F), +86-10-88396077 (Li JJ)
Fax: +86-519-68870671 (Hua F), +86-10-68331730 (Li JJ)
Received: December 26, 2021; Revised: January 28, 2022; Accepted: February 22, 2022; Published online: April 12, 2022.
© The Korean Society of Applied Pharmacology. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Diabetic cardiomyopathy (DCM) is described as abnormalities of myocardial structure and function in diabetic patients without other well-established cardiovascular factors. Although multiple pathological mechanisms involving in this unique myocardial disorder, mitochondrial dysfunction may play an important role in its development of DCM. Recently, considerable progresses have suggested that mitochondrial biogenesis is a tightly controlled process initiating mitochondrial generation and maintaining mitochondrial function, appears to be associated with DCM. Nonetheless, an outlook on the mechanisms and clinical relevance of dysfunction in mitochondrial biogenesis among patients with DCM is not completely understood. In this review, hence, we will summarize the role of mitochondrial biogenesis dysfunction in the development of DCM, especially the molecular underlying mechanism concerning the signaling pathways beyond the stimulation and inhibition of mitochondrial biogenesis. Additionally, the evaluations and potential therapeutic strategies regarding mitochondrial biogenesis dysfunction in DCM is also presented.
Keywords: Mitochondrial biogenesis, Diabetes, Cardiomyopathy, PGC-1α, Diabetic cardiomyopathy


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