Biomolecules & Therapeutics  https://doi.org/10.4062/biomolther.2021.089
The Role of Adiponectin in the Skin
Jieun Oh1,†, Yeongyeong Lee1,†, Sae-Woong Oh2,†, TianTian Li1, Jiwon Shin1, See-Hyoung Park3,* and Jongsung Lee1,2,*
1Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon 16419,
2Molecular Dermatology Laboratory, Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon 16419,
3Department of Bio and Chemical Engineering, Hongik University, Sejong 30016, Republic of Korea
*E-mail: bioneer@skku.edu (Lee J), imsesame@gmail.com (Park SH)
Tel: +82-31-290-7861 (Lee J), +82-44-860-2126 (Park SH)
Fax: +82-31-290-7870 (Lee J), +82-44-866-6940 (Park SH)
The first three authors contributed equally to this work.
Received: May 8, 2021; Revised: July 29, 2021; Accepted: August 20, 2021; Published online: September 28, 2021.
© The Korean Society of Applied Pharmacology. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Adiponectin (Ad), a 30 kDa molecule, is an anti-diabetic adipokine; although derived from adipose tissue, it performs numerous activities in various other tissues. It binds to its own receptors, namely adiponectin receptor 1(AdipoR1), adiponectin receptor 2 (AdipoR2), and T-cadherin (CDH13). Ad plays several roles, especially as a regulator. It modulates lipid and glucose metabolism and promotes insulin sensitivity. This demonstrates that Ad has a robust correlation with fat metabolism. Furthermore, although Ad is not in direct contact with other tissues, including the skin, it can be delivered to them by diffusion or secretion via the endocrine system. Recently it has been reported that Ad can impact skin cell biology, underscoring its potential as a therapeutic biomarker of skin diseases. In the present review, we have discussed the association between skin cell biology and Ad. To elaborate further, we described the involvement of Ad in the biology of various types of cells in the skin, such as keratinocytes, fibroblasts, melanocytes, and immune cells. Additionally, we postulated that Ad could be employed as a therapeutic target to maintain skin homeostasis.
Keywords: Adiponectin, Keratinocyte, Melanocyte, Fibroblast, Innate immunity, Adaptive immunity


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