Biomolecules & Therapeutics  https://doi.org/10.4062/biomolther.2021.125
Systematic Review of Recent Lipidomics Approaches Toward Inflammatory Bowel Disease
Eun Goo Lee, Young Cheol Yoon, Jihyun Yoon, Seul Ji Lee, Yu-Kyoung Oh and Sung Won Kwon*
College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
*E-mail: swkwon@snu.ac.kr
Tel: +82-2-880-7844
Received: July 22, 2021; Revised: August 17, 2021; Accepted: August 18, 2021; Published online: September 27, 2021.
© The Korean Society of Applied Pharmacology. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Researchers have endeavored to identify the etiology of inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis. Though the pathogenesis of inflammatory bowel diseases remains unknown, dysregulation of the immune system in the host gastrointestinal tract is believed to be the major causative factor. Omics is a powerful methodological tool that can reveal biochemical information stored in clinical samples. Lipidomics is a subset of omics that explores the lipid classes associated with inflammation. One objective of the present systematic review was to facilitate the identification of biochemical targets for use in future lipidomic studies on inflammatory bowel diseases. The use of high-resolution mass spectrometry to observe alterations in global lipidomics might help elucidate the immunoregulatory mechanisms involved in inflammatory bowel diseases and discover novel biomarkers for them. Assessment of the characteristics of previous clinical trials on inflammatory bowel diseases could help researchers design and establish patient selection and analytical method criteria for future studies on these conditions. In this study, we curated literature exclusively from four databases and extracted lipidomics-related data from literature, considering criteria. This paper suggests that the lipidomics approach toward research in inflammatory bowel diseases can clarify their pathogenesis and identify clinically valuable biomarkers to predict and monitor their progression.
Keywords: Crohn’s disease, Ulcerative colitis, Inflammatory bowel disease, Lipidomics, Mass spectrometry, Systematic review


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