Biomolecules & Therapeutics
Eriodictyol Inhibits the Production and Gene Expression of MUC5AC Mucin via the IκBα-NF-κB p65 Signaling Pathway in Airway Epithelial Cells
Chawon Yun1, Hyun Jae Lee2,* and Choong Jae Lee1,*
1Department of Pharmacology, School of Medicine, Chungnam National University, Daejeon 35015
2Smith Liberal Arts College and Department of Addiction Science, Graduate School, Sahmyook University, Seoul 01795, Republic of Korea
*E-mail: (Lee HJ), (Lee CJ)
Tel: +82-2-3399-1910 (Lee HJ), +82-42-580-8255 (Lee CJ)
Fax: +82-2-3399-1909 (Lee HJ), +82-42-585-6627 (Lee CJ)
Received: May 13, 2021; Revised: August 11, 2021; Accepted: August 28, 2021; Published online: September 27, 2021.
© The Korean Society of Applied Pharmacology. All rights reserved.

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In this study, we investigated whether eriodictyol exerts an effect on the production and gene expression of MUC5AC mucin in human pulmonary epithelial NCI-H292 cells. The cells were pretreated with eriodictyol for 30 min and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 h. The effect of eriodictyol on PMA-induced nuclear factor kappa B (NF-κB) signaling pathway was also investigated. Eriodictyol suppressed the MUC5AC mucin production and gene expression induced by PMA via suppression of inhibitory kappa Bα degradation and NF-κB p65 nuclear translocation. These results suggest that eriodictyol inhibits mucin gene expression and production in human airway epithelial cells via regulation of the NF-κB signaling pathway.
Keywords: MUC5AC, Pulmonary mucin, Eriodictyol

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