The Korean Society of Applied Pharmacology 2011; 19(3): 348-356  
Aqueous Extracts of Liriope platyphylla Are Tightly-Regulated by Insulin Secretion from Pancreatic Islets and by Increased Glucose Uptake through Glucose Transporters Expressed in Liver Hepatocytes
Ji Eun Kim1, So Hee Nam1, Sun Il Choi1, In Sik Hwang1, Hye Ryun Lee1, Min Ju Jang2, Chung Yeol Lee1,2, Hong Ju Soon1,2, Hee Seob Lee2,3, Hae Sung Kim4, Byeong Cheol Kang5, Jin Tae Hong6 and Dae Youn Hwang1,2,*
1College of Natural Resources & Life Science, 2Wellbeing Products RIS Center, Pusan National University, Miryang 627-706, 3College of Human Ecollogy, Pusan National University, Busan 609-735, 4College of Nanotechnology, Pusan National University, Miryang 627-706, 5Department of Experimental Animal Research, Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, 6College of Pharmacy, Chungbuk National University, Chungju 361-763, Republic of Korea
Dae Youn Hwang
Received: March 31, 2011; Revised: June 14, 2010; Accepted: July 20, 2011; Published online: July 31, 2011.
© The Korean Society of Applied Pharmacology. All rights reserved.

Open Access
Abstract
Liriope platyphylla is a medical herb that has long been used in Korea and China to treat cough, sputum, neurodigenerative disorders, obesity and diabetes. The aims of this study were to study the antidiabetic effects of the aqueous extract of L. platyphylla (AEtLP) through pancreatic and extrapancreatic actions. AEtLP were orally administrated to ICR mice once a day for 7 days. Of three different concentrations of AEtLP, only 10% AEtLP were low toxic to liver, based on body weight and serum biochemical analyses. However, 10% AEtLP-treated mice displayed signifi cant reduction of the glucose concentration and increased insulin concentration; no changes were noted using 5% and 15% AEtLP. Also, the increase of glucose transporter (Glut)-1 expression in liver was dependent on the concentration of AEtLP, and was regulated by the phosphorylation of Akt. The lowest expression of Glut-3 was observed in 15% AEtLP treated mice, followed by 10% AEtLP- and 5% AEtLP-treated mice. This pattern of Glut-3 expression was roughly in accord with the phosphorylation of c-Jun N-teminal kinase (JNK) in the mitogen-activated protein kinase (MAPK) pathway. Furthermore, a signifi cant rise of the superoxide dismutase activity (SOD) was detected in AEtLP-treated mice. The fi ndings suggest that AEtLP should be considered as a diabetes therapeutic candidate to induce insulin secretion from pancreatic β-cells and glucose uptake in liver cells.
Keywords: Liriope platyphylla, Insulin, Diabetes, Glucose transporter, Signaling pathway

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