The Korean Society of Applied Pharmacology 2011; 19(3): 324-330  
Inhibition of Experimental Lung Inflammation and Bronchitis by Phytoformula Containing Broussonetia papyrifera and Lonicera japonica
Hyun Jeong Ko1, Jeong Ho Jin1, Oh Song Kwon1, Jong Taek Kim2, Kun Ho Son3 and Hyun Pyo Kim1,*
1College of Pharmacy, 2College of Veteniary Medicine, Kangwon National University, Chuncheon 200-701, 3Deparment Food and Nutrition, Andong National University, Andong 760-749, Republic of Korea
Hyun Pyo Kim
Received: April 18, 2011; Revised: June 13, 2011; Accepted: June 13, 2011; Published online: July 31, 2011.
© The Korean Society of Applied Pharmacology. All rights reserved.

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Abstract
Broussonetia papyrifera and Lonicera japonica have long been used in the treatment of infl ammatory disorders, especially respiratory infl ammation, in Chinese medicine. Previously, phytoformula (BL) containing B. papyrifera and L. japonica was found to exert strong anti-infl ammatory activity in vitro and in vivo. In this study, the effects of BL on lung infl ammation including bronchitis were examined in vitro and in vivo. BL (10-100 ?g/ml) inhibited nitric oxide (NO) production of lipopolysaccharide (LPS)-treated alveolar macrophages, MH-S cells, primarily by down-regulating inducible NO synthase. BL also inhibited production of the proinfl ammatory cytokines, TNF-α and IL-6. Against an animal model of pleural cavity infl ammation, BL (200-400 mg/kg) signifi cantly inhibited 5 h and 24 h carrageenan-induced pleurisy in rats when administered orally. Additionally, BL inhibited experimental bronchitis induced by intratracheal instillation of LPS to rats. Taken together, these results indicate that BL may be effective for the treatment of human lung infl ammation as well as bronchitis.
Keywords: Broussonetia papyrifera, Lonicera japonica, Lung infl ammation, Bronchitis


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