Syndecan as a Messenger to Link Diabetes and Cancer

The Korean Society of Applied Pharmacology 2011; 19(3): 267-273

Sung-Jin Kim^* and OS Sethu Raman

Department of Pharmacology and Toxicology, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea

Sung-Jin Kim

Received: March 31, 2011; Revised: May 19, 2011; Accepted: May 19, 2011; Published online: July 31, 2011.

Open Access

Abstract: Syndecans are membrane-anchored proteoglycans and implicated in the pathogenesis of cancer progression and metastasis. Syndecans also play important roles in interacting with growth factors, extracellular matrix and other cell surface molecules such as IGF-1 receptor. In the present review, we discuss about the syndecan structure, their role in signaling with other receptors, in addition to its general biology. The emerging roles of syndecans in the pathophysiology of human diseases, especially insulin resistance, diabetes and cancer is discussed.; Keywords: Syndecans, Insulin resistance, Diabetes and cancer

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