Fig. 1. Overview of CART gene structure and CART peptide 3D structure. (A) The schematic diagram of CART gene and its proximal promoter transcription factor binding sites. The diagram shown here is based on the genomic structure of mouse CART genes and adapted from works of Dominguez et al. The CART gene is composed of 3 exons and 2 introns, in which several transcription binding sites are presented, and the transcription initiation site is shown as +1. The diagram is not to scale. (B) The 3D structure of human CART peptide chain A, extending from residues 76–116 of C-terminal domain. The structure is downloaded from protein data bank (PBD, id: 1hy9).
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