Fig. 3. Comprehensive profiling of tumor metabolism. Following non-invasive imaging with PET, MRI, MRS, CT patients undergo resection or biopsy of the tumor. Tissue analysis of the resected or biopsied tumor includes metabolomics, qIHC and gene expression analysis. Comprehensive tumor profiling identified preference for glucose in poorly vascularized areas of the tumor, compared to well vascularized tumors that used both glucose and alternative metabolites to fuel their growth.
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