Fig. 2. Two experiments related with cancer energy metabolism. (A) ALDH1L1 in one-carbon pathway produces abundant cytosolic NADH which generates ATP following to transport to mitochondria via MAS in NSCLC. By combined inhibition of ALDH and mitochondrial complex I, xenograft cancer model showed significant regression of tumor growth (). (B) GLS1 supplies abundant glutamate for MAS to produce ATP that is needed for pyrimidine synthesis in NSCLC. By combined inhibition of GLS1 and TYMS, xenograft cancer model showed significant regression of tumor growth (). THF: tetrahydrofolate, GLS1: glutaminase 1, TYMS: thymidylate synthetase, ALDH: aldehyde dehydrogenase, CPSII: carbamoylphosphate synthase II, *: ATP sensitive enzyme, MAS: malate aspartate shuttle, ETC: electron transfer complex, BPTES: bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide.
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