Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 3. Concentration-dependent effects of quercetin and its glycosides on IACh. (A) The representative trace of quercetin- or quercetin gly-coside- (30 μM each) mediated effects on IACh. IACh in oocytes expressing the α7 nAChR was elicited at a holding potential of ?80 mV for 30 s in the presence of 200 μM ACh. Quercetin and its glycosides were pre-applied 30 s before ACh application. (B) The representative trace of quercetin- and quercetin glycoside- (300 μM each) mediated effects on IACh. IACh in oocytes expressing the α7 nAChRs was elicited at a holding potential of ?80 mV for 30 s in the presence of 200 μM ACh. Quercetin and its glycosides were pre-applied 30 s before ACh application. Traces represent six separate oocytes from three different batches of frogs. (C?D) Concentration-dependent effects of quercetin and quercetin glycosides on IACh. The solid lines were fit using the Hill equation. Each point represents the mean ± S.E.M. (n=9?12/group).
Biomolecules & Therapeutics 2016;24:410~417 https://doi.org/10.4062/biomolther.2015.153
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