Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 2. Rhomboid protein iRhoms regulate the trafficking and maturation of TNF-a converting enzyme (TACE). iRhoms bind to TACE, which promotes its exit from ER to Golgi. Within the Golgi, TACE is processed by furin into its mature form. At the plasma membrane, TACE cleaves the membrane-bound form of TNF-α to generate soluble TNF-α, which binds to TNFR.
Biomolecules & Therapeutics 2016;24:109~114
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