Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 2. Integration of intracellular mitochondrial function rely on both anterograde and retrograde signaling pathway. The anterograde signaling system transduces signals from environments (external and/or internal) to nucleus, activating genomic program to adjust mitochondrial functioning. The retrograde signaling system monitors the function of mitochondria and transduce signals back to the nucleus. Studies on cytoplasmic transducers are actively pursued. See text for details.
Biomol Ther (Seoul) 2014;22:491~496
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