Fig. 4. Effects of COL7A1 on extracellular matrix gene expression and collagen synthesis. (A) Heatmap of COL7A1-, COL1A1-, or COL21A1-treated human dermal fibroblasts (HDFs) and a description. (B) Relative procollagen I production after treatment with 160 ppm of collagen peptides. (C) Differentially expressed genes (DEGs) in COL7A1-treated HDFs. (D) Volcano plot of COL7A1-treated HDFs compared to vehicle groups. (E) Relative procollagen synthesis after treatment with 80 and 160 ppm of COL7A1. ***p<0.001 versus the vehicle group, one-way ANOVA. Error bars represent the mean ± sd.
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