Fig. 3. COL7A1 promotes healthy aging in C. elegans. Effects of COL1A1, COL7A1, and COL21A1 versus vehicle on (A) average speed (***p<0.001 and ****p<0.0001 versus the vehicle group, one-way analysis of variance [ANOVA], n=20 worms×three assays each), (B) number of body bends (**p<0.01 and ****p<0.0001 versus the vehicle group, one-way ANOVA, n=20 worms×three assays each), (C) number of progeny (p>0.05, Student’s t-test, three independent measurements), (D) oxidative stress resistance (**p<0.01 and ****p<0.0001 versus the vehicle group, one-way ANOVA, n=20 worms×nine measurements each), (E) thermotolerance (*p<0.05 and ****p<0.0001 versus the vehicle group, one-way ANOVA, n=20 worms×nine measurements each), (F) superoxide dismutase (SOD) activity (*p<0.05 and **p<0.01 versus vehicle, Student’s t-test, n=3 worm pellets), (G) catalase activity (*p<0.05 and **p<0.01 versus vehicle, Student’s t-test, n=3 worm pellets), (H) lipofuscin content (**p<0.01 and ****p<0.0001 versus the vehicle group, one-way ANOVA, n=20 worms×three assays each), and (I) triglyceride (TG) content ***p<0.001 and ****p<0.0001 versus the vehicle group, one-way ANOVA, n=3 worm pellets). Error bars represent the mean ± standard deviation (sd).
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