Fig. 4. Mice treated with atractylodin overcome glucose intolerance. (A) Fasting serum glucose levels after sacrificing mice that were fasted for more than 16 h. (B) Fasting serum insulin levels. (C) HOMA-IR index. (D) Glucose tolerance test (GTT). GTT curve (left) and area under the curve (AUC, right). (E) Insulin tolerance test (ITT). ITT curve (left) and % of area under the curve (AUC, right). Data are presented as mean ± SEM (n=8-9). Statistical analysis was performed using one-way ANOVA with Tukey’s post-hoc test. **p<0.01: compared with ND+Veh; #p<0.05, ##p<0.01: compared with HFD+Veh. (F) Principal component analysis (PCA) comprising gene expression patterns in the livers of HFD-fed mice treated with vehicle (HFD+Veh) or 10 mg/kg atractylodin (HFD+AT10) (n=3). (G) Heatmap of gene expression changes in the glucose metabolism upon atractylodin treatment.
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