Fig. 2. Effect of pyronaridine on phorbol 12-myristate 13-acetate (PMA)-induced MUC5AC production in NCI-H292 cells. NCI-H292 cells were pretreated with varying concentrations of pyronaridine for 30 min and then stimulated with PMA (10 ng/mL) for 24 h. Cell lysates were collected for the measurement of MUC5AC mucin production by enzyme-linked immunosorbent assay (ELISA). Each bar represents a mean ± SEM of three culture wells compared with that of the control set at 100%. Three independent experiments were performed, and representative data are shown. *Significantly different from that of the control (p<0.05). +Significantly different from that with PMA treatment alone (p<0.05). Cont: control, P: pyronaridine, concentration unit is μM.
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