Table 2 Examples of applications of decellularized matrices of xenobiotic origin
| Research area | Matrix source | Matrix application | Effectiveness | References |
|---|---|---|---|---|
| Animal | PADM | Treatment of hernia defects in pigs | Grafts replaced by newly formed connective tissue | Melkonyan |
| Animal | AFSM | Treatment of deep second-degree burn wounds in male KM mice | No adverse acute pro-inflammatory reactions | Wei |
| Animal | GACM | Reconstruction of cartilage defects in rabbits | No significant immune response or tissue rejection | Das |
| Animal | PACM, PADM (JiangSu Unitrump Biomedical Technology Co., Ltd., Jiangsu, China) | Subcutaneous implantation in the abdominal rib area of goats | Lower PADM-induced immune response | Wang |
| Animal | Cell-free rabbit dermal matrix | Treatment of lateral ventral hernia in buffaloes | Post-operative rehabilitation | Kumar |
| Animal | PADM (Conexa Reconstructive Tissue Matrix; Tornier Inc, Edina, MN, USA) | Repair of supraspinatus tendon defects of the rotator cuff in the African green monkey | No Hypersensitivity Reaction | Xu |
PADM, porcine acellular dermal matrix; AFSM, acellular fish skin matrix; GACM, goat acellular cartilage matrix; PACM, porcine acellular cartilaginous matrix.