Fig. 4. Mitigation of tumor growth by intratumor injection of PPTEE-containing microemulsion (ME). QS-21- or PPTEE-containing ME was injected every 3 days into MC38-bearing C57BL/6 mice, starting 7 days after tumor inoculation. Tumor size (A) and mass (B) were measured until the mice were sacrificed. A TUNEL assay was performed on tumor tissues from each group of tumor-bearing mice. Representative sections of tumor tissue slides were shown (×400, scale bar: 50 µm) (C). Tumor-infiltrating myeloid-derived suppressive cells were analyzed by flow cytometry (D). The data is presented as mean ± SEM. Statistical analysis was conducted using two-way ANOVA for (A) and one-way ANOVA for (B-D), with significance: non-significant (ns) when p≥0.05, *p<0.05, **p<0.01, ***p<0.001.
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