Fig. 4. Mean Vmax, Km and CLint values for tofacitinib metabolism in (A) hepatic and (B) intestinal microsomes from control (CON), loganin (LGN), acute kidney injury (AKI) and acute kidney injury-loganin (AKI-LGN) rats (n=3 per group). Data are shown as means ± standard deviations of three independent experiments. Vmax, maximum velocity; Km, apparent Michaelis–Menten constant; CLint, intrinsic clearance. *p<0.05; **p<0.01; ***p<0.001.
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