Fig. 2. (A) Body weight, plasma chemistry data, creatinine clearance (CLCR), plasma protein binding of tofacitinib, and relative liver and kidney weights in the four groups of rats (control (CON), loganin (LGN), acute kidney injury (AKI) and acute kidney injury-loganin (AKI-LGN); n=3 each). Data are shown as means ± standard deviations. (B) Liver and kidney biopsy samples from rats in the four groups. Black arrows indicate immune cell infiltration and stars indicate tissue damage, including massive cell death. BUN, blood urea nitrogen; BW, body weight; GOT, glutamate oxaloacetate transaminase; GPT, glutamate pyruvate transaminase; SCR, serum creatinine concentration. *p<0.05, **p<0.01, ***p<0.001.
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