Fig. 3. Inhibitory effects of sesquiterpene lactones on STAT3 activation in MDA-MB-231 cells. (A, B) The cells were treated with sesquiterpene lactones for 4 h. Cell lysates were subjected to western blot analysis to determine the p-STAT3 (Tyr705) and STAT3 protein levels. β-actin was used as a loading control. (C) The western blot analysis quantified the levels of p-STAT3 and STAT3 proteins at 10 μM of sesquiterpene lactone. (D) Correlation analysis between relative p-STAT3 at 10 μM and 48-h anti-proliferative effects at 50 μM in MDA-MB-231 cells of sesquiterpene lactones.
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