Fig. 2. Anti-proliferative effects of sesquiterpene lactones in human breast cancer cell lines. (A) Anti-proliferative effects of sesquiterpene lactones in MDA-MB-231 cells after 48 h. (B) The IC50 values for anti-proliferative effects of sesquiterpene lactones in MDA-MB-231, BT-549, and MCF-7 cells. The cells were treated with varying concentrations of sesquiterpene lactones (ranging from 0 to 50 μM) for 48 h and 72 h, and the effects of sesquiterpene lactones on cell viability were measured. The results are presented as the mean ± SD of three independent experiments. *p<0.05 and **p<0.01 indicate the statistical significance compared to the IC50 value determined in MCF-7 cell line. N.D., not determined.
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