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Fig. 5. Mangiferin ameliorated mtROS production and increased GSH/GSSG ratio in H2O2-treated ARPE-19 cells. Cells exposed with or without mangiferin (20 ┬ÁM) for 1 h were stimulated with H2O2 (0.5 mM) for 1 h (A-C) or 24 h (D). (A, B) Representative histograms of flow cytometry (A) and the frequency of DCF-positive cells (B). (C) Representative fluorescence images of ROS production. (D) Bar chart indicated the GSH/GSSG ratio following the exposure to H2O2 and pretreatment with mangiferin. All data are represented as mean SD from triplicate experiments (***p<0.001 compared with the control group. ###p<0.001 compared with the H2O2-treated group).
Biomolecules & Therapeutics 2024;32:329~340 https://doi.org/10.4062/biomolther.2023.175
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