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Fig. 4. Mangiferin attenuated H2O2-induced mitochondrial impairment in ARPE-19 cells. Cells exposed with or without mangiferin (20 ┬ÁM) for 1 h were treated with H2O2 (0.5 mM) for 24 h. (A, B) Representative histograms (A) and JC-1 monomer ratios (B) of flow cytometry using JC-1 staining in each treatment group. (C) The expression of cytochrome c in the mitochondrial and cytosolic fractions was investigated by immunoblotting. All data are represented as mean SD from triplicate experiments (***p<0.001 compared with the control group. ###p<0.001 compared with the H2O2-treated group).
Biomolecules & Therapeutics 2024;32:329~340 https://doi.org/10.4062/biomolther.2023.175
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