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Fig. 2. Mangiferin protected H2O2-induced DNA damage in ARPE-19 cells. Cells were exposed to mangiferin (20 µM) for 1 h prior to treatment with H2O2 (0.5 mM) for 24 h. After treatment, the effect of mangiferin on H2O2-induced DNA damage was evaluated. Representative images of comet assay (A), 8-OHdG levels (B) and expression changes of γH2AX (C, D) were presented. All data are represented as mean SD from triplicate experiments (***p<0.001 compared with the control group. ###p<0.001 compared with the H2O2-treated group).
Biomolecules & Therapeutics 2024;32:329~340
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