Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Table. 1.

Table 1 Chemical structure of compounds and their inhibitory properties on MERS-CoV shown in Fig. 3A using plaques inhibition assay. The cytotoxicity values represent the average from three different cultures. Cell viability measurement was based on mitochondrial activity

Compound no ID Chemical name Total plaque No. % Plaque Cytotoxicity against HEK cells
PBS 496 117.4
10% DMSO 422 100
22 24071746
{4-[(1-{[3-(4-fluorophenyl)-1H-pyrazol-5-yl]carbonyl}pyrrolidin-3-yl)methyl]phenyl}methanol
268 63.5 0.596
74 F2282-0127*
1-(4-chlorophenyl)-N-(2-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-5-oxopyrrolidine-3-carboxamide
172 40.8 0.568
73 98931397
4-[3-({4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl}carbonyl)-1-piperidinyl]-2-(3-thienylmethyl)-1H-isoindole-1,3(2H)-dione
212 50.2 0.602
75 F2282-0124*
N-(2-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-5-oxo-1-(p-tolyl)pyrrolidine-3-carboxamide
332 78.7 0.604
4 6505627
4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-2-naphthylbutanamide
316 74.9 0.603
76 F2282-0128*
N-(2-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-1-(3,4-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
276 65.4 0.520
58 57295921
3-{[4-(2-{4-[(4-benzyl-1-piperidinyl)methyl]phenoxy}ethyl)-1-piperazinyl]carbonyl}-1-methyl-4(1H)-quinolinone
304 72.0 0.602
54 F2282-0139*
N-(2-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-1-(3-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
392 92.9 0.578
35 30625545
N-(2-fluorobenzyl)-3-{1-[4-(3-hydroxy-3-methyl-1-butyn-1-yl)benzoyl]-3-piperidinyl}propanamide
368 87.2 0.580
78 F2068-0373
N-(2-((4-(4-fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide
396 93.8 0.574
26 25947446
N-(3-{4-[({[5-(methoxymethyl)-2-thienyl]carbonyl}amino)methyl]-5-methyl-1,3-oxazol-2-yl}phenyl)-1-methyl-3-piperidinecarboxamide
468 110.9 0.587
60 66172782
(4-{2-[4-(2,3-dihydro-1-benzofuran-2-ylcarbonyl)-1-piperazinyl]ethoxy}benzyl)methyl(6-quinolinylmethyl)amine
452 107.1 0.572
69 78170314
methyl 5-{[3-(2-hydroxyethoxy)benzyl]amino}-1-(2-phenylethyl)-3-[(tetrahydro-2-furanylcarbonyl)amino]-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
388 91.9 0.529
61 67801543
N-[3-(4-{[3-(4-fluorophenyl)-3-(2-furyl)propyl]amino}-1-piperidinyl)phenyl]isonicotinamide
316 74.9 0.173
33 29194995
4-phenyl-N-(3-{4-[(3-pyridinylmethyl)amino]-1-piperidinyl}phenyl)butanamide
412 97.6 0.588

*Compounds purchased from Life Chemicals Inc (Niagara-on-the-Lake, Canada). The rest of compounds were purchased from Chembridge (San Diego, CA, USA).

Biomolecules & Therapeutics 2024;32:262~265 https://doi.org/10.4062/biomolther.2024.001
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