Fig. 1. The impact of altered UPR activation on cellular processes over ER regulation. Altered UPR activation, with its capacity to tightly modify ER regulation, provided valuable insights into the diverse cellular processes governed by the UPR. The functional roles associated with UPR activation encompass: transcriptional upregulation of UPR-related proteins, attenuation of general translation, and enhancement of ER capacity. Furthermore, if the proper restoration of ER function is not achieved, the UPR has the potential to induce cell death.
© Biomolecules & Therapeutics
