Fig. 2. Effect of salmon nasal cartilage proteoglycan (SPG) on proteins related to keratinization and water movement in a UVB-irradiated mouse model. (A) Immunohistological changes in filaggrin, involucrin, and AQP3 in the skin of SKH-1 mice exposed to UVB irradiation for 8 weeks. (×40; bar size 100 μm). (B) Western blot was used to measure the expression levels of filaggrin, involucrin, and AQP3 in skin of SKH-1 mice exposed to UVB irradiation for eight weeks. All proteins were normalized to GAPDH. Ctrl: saline administration without 200 mJ/cm2 UVB irradiation, NC: saline administration with 200 mJ/cm2 UVB irradiation, PC: 1000 mg/kg collagen peptide (CP) administration with 200 mJ/cm2 UVB irradiation, SPG: 1 and 5 mg/kg salmon nasal cartilage proteoglycan. The values are presented as mean ± SEM (n=8). *p<0.05 and **p<0.01 vs. Ctrl, #p<0.05 and ##p<0.01, vs. NC.
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