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Fig. 1. Effect of salmon nasal cartilage proteoglycan (SPG) on skin wrinkle formation, TEWL, hydration, and histological changes in UVB-irradiated mouse model. (A) Schematic diagram of UVB-irradiated SKH-1 hairless mouse model. (B) Changes in body weight during the in vivo study. (C) Photographs of the skin surface and replica impression of the mouse dorsal skin. Histogram of dorsal wrinkles using a video camera and analyzed using ImageJ. (D) Changes in TEWL and hydration after repeated irradiation with UVB using the Derma Combo System. (E) Histological changes in the dorsal skin exposed to UVB irradiation after eight weeks. Ctrl: saline administration without 200 mJ/cm2 UVB irradiation, NC: saline administration with 200 mJ/cm2 UVB irradiation, PC: 1000 mg/kg collagen peptide (CP) administration with 200 mJ/cm2 UVB irradiation, SPG: 1 and 5 mg/kg salmon nasal cartilage proteoglycan. The values are presented as mean ± SEM (n=8). *p<0.05, **p<0.01, and ***p<0.001 vs. Ctrl, #p<0.05, ##p<0.01, and ###p<0.001 vs. NC.
Biomolecules & Therapeutics 2024;32:249~260 https://doi.org/10.4062/biomolther.2024.010
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