Fig. 3. AMPK mediates anti-aging effects upon AMPK activation. Treg cells show elevated IL-2Rα signaling, which fortifies the function of STAT5. This leads to amplification of IL-2 signaling to enhance the stability and function of Treg cells. Additionally, AMPK inhibits a critical regulator of inflammation, NF-κB, by inducing the activity of SIRT-1, p53, FOXO, and PGC-1α. Moreover, AMPK targets FOXO and DAF-16 to increase lifespan in C. elegans and mammals. The figure is created with BioRender.com.
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