Fig. 2. AMPK ameliorates allergy severity. AMPK-mediated inhibition of mTORC2 leads to increased SOCS5 expression, which represses STAT6 to hamper GATA3-induced Th2 differentiation and allergy exacerbation. In this context, AMPK activators, chlorogenic acid and AICAR, phosphorylate Acetyl-CoA carboxylase (ACC), altering the equilibrium between Acetyl-CoA and Malonyl-CoA, which subsequently impacts the activity of CPT-1. These treatments alleviate shrimp allergy in mouse model. The figure is created with BioRender.com.
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