Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Table. 1.

Table 1 Inhibition of different cancer types via AMP-activated protein kinase (AMPK) activation and the underlying mechanisms

Cancer types AMPK activation compounds Mechanisms References
Breast cancer Honokiol Inhibits the invasiveness and migration of breast cancer via the liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK)/pS6K axis in MCF7 and MDA-MB-231 cells Nagalingam et al., 2012
Breast cancer Demethoxycurcumin and nordihydroguaiaretic acid Inhibit the AMPK/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway in MDA-MB-231, MCF-7, and Bcap37 cells Zhang et al., 2012; Shieh et al., 2013
Hepatocellular carcinoma (HCC) Antroquinonol Inhibits mTOR translational pathway leading to the G1 arrest of cell cycle and subsequent cell apoptosis via the AMPK/mTOR/p70-S6 kinase and 4EBP1 pathways in HepG2 cells Chiang et al., 2010
Esophageal Cancer Cordycepin Increases chemosensitivity to cisplatin by activating AMPK and inhibiting the AKT signaling pathway in HK, K180, K70, and ECA109 cells Gao et al., 2020
Colon cancer Curcumin Inhibits tumor growth via the AMPK/pAKT/cyclooxygenase 2 (COX-2) pathway in HT-29 cells Lee et al., 2009
Colon cancer Magnolol and quercetin Induce apoptosis via the AMPK/p53/Bax pathway in HCT-116 and HT-29 cells Kim et al., 2010; Park et al., 2012
Colon cancer Widdrol Induces apoptosis via the activation of caspase-3/7 and caspase-9 through AMPK activation in HT-29 cells Kang et al., 2012
Ovarian cancer GANT61 Elevates chemosensitivity to cisplatin by regulating the AMPK pathway in Caov-3 and SKOV-3 cells Zhu et al., 2022
Ovarian and colon cancers Curcumin Induces cell death via the AMPK/p53 pathway in CaOV3 cells and HT-29 cells Song et al., 2005; Pan et al., 2008
Lung cancer Metformin-salicylate Phosphorylates ACC and inhibits de novo lipogenesis via AMPK activation in A549 and H1299 cells O'Brien et al., 2015
Hepatoma and colon cancer Cryptotanshinone Induces autophagic cell death via the AMPK/mTOR axis in HepG2 and HCT116 cells Park et al., 2014
Breast cancer Ginsenoside-Rg2 Induces the ROS-AMPK signaling pathway and inhibits extracellular signal-regulated kinase (ERK)1/2 and AKT activation-mediated cell proliferation and cell cycle progression in MCF-7 breast cancer cells Jeon et al., 2021
Melanoma Berberine Inhibits metastasis via the AMPK/ERK/COX2 pathway in B16F10 murine melanoma and A375 human melanoma cells Kim et al., 2012
Melanoma Ginsenoside 20-O-β-D-Glucopyranosyl-20(S)-Protopanaxadiol Induces autophagic cell death via AMPK/Janus kinase (JNK) pathway activation in SK-MEL-28 cells Kang et al., 2014
Leukemia Tanshinone IIA Induces autophagic cell death via AMPK/mTOR/p70-S6 kinase in KBM-5 cells Yun et al., 2014
Breast cancer, melanoma, and colon cancer Metformin Endoplasmic reticulum (ER)-associated programmed cell death ligand-1 (PDL1) glycosylation and degradation by metformin-activated AMPK in 4T1, B16F10, and CT26 cells Cha et al., 2018
Renal cancer Hispidulin Sensitizes cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis via the AMPK/USP51 axis in CC-2559 cells Woo et al., 2019
Prostate cancer BI-9774, MT 63-78 Inhibits lipogenesis via AMPK activation in C4–2, C4–2b, LNCaP cells Zadra et al., 2014; Penfold et al., 2023
Prostate cancer Metformin-salicylate Suppresses the ACC-DNL, mTOR-p70s6k/4EBP1, and HIF1α pathways Tsakiridis et al., 2021
Thyroid cancer AICAR Inhibits C-X-C motif chemokine ligand 8 (CXCL8) secretion and suppresses CXCL8-induced neoplastic cell migration Awwad et al., 2018
Biomolecules & Therapeutics 2024;32:171~182
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