Fig. 2. DMK increases the production of α-ketoglutarate in HaCaT cells without affecting the viability of HaCaT cells. (A) Chemical structures of α-ketoglutarate and dimethyl α-ketoglutarate (DMK). (B) HaCaT cells (1×106 cells) were exposed to α-ketoglutarate and DMK at various times, and the amount of intracellular α-ketoglutarate was measured (n=3). (C) HaCaT cells (1×104 cells) were exposed to DMK at various concentrations, and the viability was measured by the MTT assay (n=3). *p<0.05 and **p<0.01 vs Control (DMSO).
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