Fig. 5. Rosmarinic acid (RA) inhibits UVB irradiation-induced oxidative damage to components in the dorsal mouse skin tissue. Mice were treated with RA (0.01 or 0.1 mg/mL) or padimate O prior to UVB irradiation. (A) Protein expression of phospho-histone H2A.X, (B) 8-OHdG (indicator of oxidative DNA damage) levels, (C) formation of protein carbonyls (markers of protein oxidation), and (D) 8-isoprostane (marker of lipid peroxidation) levels were assessed. (A) Actin was used as a loading control for phospho-histone H2A.X. (B-D) *Significantly different compared to the non-irradiated control group (p<0.05), and **significantly different compared to the irradiated control group (p<0.05).
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