Fig. 7. The PI BTZ induces neurogenesis and apoptosis in NSCs. Proteasome inhibition induced by BTZ increased TUBB3 protein levels in NSCs. In addition, BTZ increased the percentage of neurons and TUBB3 expression by elevating the activation of CREB, Bdnf transcripts, and BDNF protein level in proliferating NSCs but not in differentiating NSCs. In contrast, BTZ inhibited the process of NSC proliferation and induced apoptosis by reducing the Bcl-2/Bax ratio.
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