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Fig. 2. Disturbance of bcl-2 family proteins by domperidone. (A) TNBC BT-549 and CAL-51 cells were treated with domperidone (0, 10, 20, and 50 µM) for 24 h and the levels of Bcl-2 family proteins Bcl-2, Bcl-xL, Bax, and Bak were monitored by immunoblot. β-Actin was used as the loading control. (B) The mitochondrial membrane potential was measured by flow cytometry with DiOC6 staining. The bar graphs represent the mean ± SD (n=3). *p<0.05 compared to the control group.
Biomolecules & Therapeutics 2023;31:692~699
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