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Table. 3.

Table 3 Summary of the volatile general anesthetics modulating TRP channels

VGAs TRPA1 TRPV1 TRPM3 TRPM8 TRPC5
Effects: CGRP release, respiratory inhibition Effects: CGRP release, hyperthermia Effects: Hypothermia respiratory inhibition
Isoflurane Activation Enhancement Activation (Inhibition by prolonged exposure)
Desflurane Activation Enhancement Activation (Inhibition by prolonged exposure)
Sevoflurane Enhancement Inhibition Activation (Inhibition by prolonged exposure)
Halothane Activation Inhibition Activation (Inhibition by prolonged exposure) Inhibition
Chloroform Inhibition Inhibition
Biomolecules & Therapeutics 2024;32:192~204 https://doi.org/10.4062/biomolther.2023.118
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