Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 3. The pheromone sensing mechanism by the TRPC2 channel. In the vomeronasal organ, the pheromone signal transduction pathway begins at vomeronasal receptors. Upon pheromones binding, the V1R/V2R activates G-proteins. The activated G-proteins stimulate the cleavage of PIP2 into IP3 and DAG via PLC. DAG activates TRPC2 channel, leading to influx of cationic ions. Ca2+/calmodulin directly inhibits the activity of TRPC2. The human TRPC2 gene is a pseudogene that generates premature stop codons, resulting in a severely truncated protein. DAG, diacylglycerol; GDP, guanosine diphosphate; GTP, guanosine triphosphate; Ins(1,4,5)P3, inositol 1,4,5-trisphosphate; PIP, phosphatidylinositol-4,5-bisphosphate; PLC, phospholipase C; CaM, calmodulin.
Biomolecules & Therapeutics 2024;32:192~204
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