Fig. 2. Effects of AB23Ac treatment on airway hyper-responsiveness to methacholine in an OVA-induced murine asthma model and IgE levels in serum. (A) Airway hyper-responsiveness was measured as Penh (enhanced pause) in mice treated with AB23Ac (60 mg/kg) or PBS after challenge with increasing concentrations of methacholine. PBS: PBS-treated mice, OVA: OVA-challenged mice, OVA+AB23Ac sensitization: OVA-challenged mice treated AB23Ac before sensitization, OVA+AB23Ac challenge: OVA-challenged mice treated AB23Ac before challenge. (B) ELISA was used to measure the protein levels of IgE in serum. The results are presented as means ± the standard error of the mean (SEM) (n=5). **p<0.01, ***p<0.001 vs. the PBS-treated group, ##p<0.01, ###p<0.001 vs. the OVA-treated group.
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