Fig. 1. AB23Ac reduces antigen-induced degranulation in RBL-2H3 mast cells. After sensitization with anti- dinitrophenyl immunoglobulin E (DNP-IgE) for 18 h, RBL-2H3 cells were challenged with dinitrophenyl-human serum albumin (DNP-HSA). AB23Ac treatment was performed at the indicated concentrations 30 min before antigen challenge. Basal degranulation shows samples without IgE and HSA, and the positive control of antigen-induced degranulation shows samples with IgE and HSA. The results are presented as means ± the standard error (SE) of three independent experiments. ***p<0.001 vs. the HSA-untreated group. #p<0.05, ##p<0.01, ###p<0.001 vs. the HSA-treated group.
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