Fig. 4. Immunization with bivalent inactivated vaccine prevents tissue damage caused by EV71 C4a infection. Mongolian gerbils were immunized twice with the bivalent inactivated EV71 C4a/CVA16 vaccine via the intramuscular route (n=4). At 1 week following the final immunization, 3-week-old gerbils were infected with EV71 C4a via the intraperitoneal route. (A) On day 5 after infection, the muscle and heart were stained with haematoxylin-eosin. (B, C) The severity of tissue damage was scored in the (B) muscle and (C) heart. Graphs show the mean ± SEM. Non-parametric test (Kruskal-Wallis followed by Dunn’s multiple comparison test) was performed; ns, not significant; *p<0.05, **p<0.01, ***p<0.001.
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