Fig. 3. Immunization with the bivalent vaccine effectively prevents viral amplification in infected tissues. Mongolian gerbils were immunized twice with the bivalent EV71 C4a/CVA16 vaccine via the intramuscular route (n=3). (A, B) At 1 week following the final immunization, (A) EV71 C4a and (B) CVA16 were used for infection via the intraperitoneal route. On day 5 after infection, viral RNA content was analysed in the brainstem, muscle, spleen, and heart. Graphs show the mean ± SEM. One-way ANOVA was performed; ###p<0.001, vehicle vs virus-infected group; ***p<0.001, virus-infected group vs immunized group.
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