Fig. 2. Immunization with the bivalent inactivated vaccine protects the host against a lethal EV71 C4a and CVA16 challenge. Mongolian gerbils were immunized twice with a bivalent EV71 C4a/CVA16 vaccine via the intramuscular route (n=8). (A, B) At 1 week following the final immunization, gerbils were challenged with a lethal dose of (A) EV71 C4a and (B) CVA16 via the intraperitoneal route. Body weight, paralytic signs, and survival were monitored daily for 20 days. Graphs show the mean ± SEM. One-way ANOVA was performed; ns, not significant; ***p<0.001, virus-infected group vs immunized group. ###p<0.001, healthy controls vs virus-infected group. A log-rank (Mantel-Cox) test was performed for the survival rate.
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