Fig. 1. Melatonin prevented AA-induced acute renal proximal tubular injury. (A) The picture of Aristolochia and the chemical structure of aristolochic acid (AA). (B) Hematoxylin-eosin (HE) and periodic acid Schiff (PAS) staining in renal sections of mice (scale bars: 50 µm). Tubular necrosis (arrow), tubular atrophy (arrowhead), and tubular casting (asterisk). (C) The treatment schedule of melatonin in AA-induced AKI mice model. (D) Coomassie blue staining detected urinary protein (Upro) at day 11 after melatonin treatment. (E) Upro and (F) serum creatinine (Scr) detection at day 11 after melatonin treatment. (G) HE and PAS staining in renal sections of mice (scale bars: 50 µm). CONT means control. Mel means melatonin. Values are means ± SEM, *p<0.05, **p<0.01, n=6.
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